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,,,,,,La,,,morfina,,,atraviesa,,,la,,,barrera,,,placentaria,,,por,,,lo,,,que,,,se,,,debe,,,administrar,,,con,,,precaucin,,,durante,,,el,,,embarazo,,,y,,,el,,,parto.,,,Los,,nios,,de,,menos,,de,,50,,kg,,de,,peso,,son,,ms,,sensibles,,a,,los,,efectos,,de,,los,,opiceos,,y,,necesitan,,un,,reajuste,,de,,la,,dosis,,en,,funcin,,de,,su,,peso,,corporal.,,Referencias.,,Contraindicaciones,,,Reacciones,,Adversas,,,Interaccin,,de,,Drogas.,,Pharmacology,,,and,,,Physiology,,,in,,,Anesthetic,,,Practice.,,,

Se,,cree,,que,,este,,metabolito,,es,,el,,responsable,,del,,desarrollo,,de,,tolerancia,,a,,la,,morfina.,,Este,,se,,caracteriza,,por,,disminucin,,de,,la,,respuesta,,al,,dixido,,de,,carbono,,aumento,,de,,la,,PaCO2,,basal,,y,,desplazamiento,,de,,la,,curva,,de,,respuesta,,al,,CO2,,a,,la,,derecha.,,Acta,,Anaesthesiol,,Scand,,1997;41:11622.,,Br,J,Anaesth,1998;81:208.,Symptomatic,and,prophylactic,treatment,of,migraine,and,tension-type,headache.,Los,,agonistas,,opiceos,,ocasionan,,un,,espasmo,,del,,esfnter,,de,,Oddi,,,que,,puede,,ocasionar,,hiperamilasemia,,,aumentando,,igualmente,,los,,niveles,,plasmticos,,de,,lipasa,,,mientras,,que,,al,,mismo,,tiempo,,puede,,haber,,una,,obstruccin,,biliar.,,Tampoco,,hay,,una,,relacin,,clara,,entre,,niveles,,plasmticos,,y,,reacciones,,adversas,,,aunque,,lgicamente,,,a,,mayores,,concentraciones,,suelen,,producirse,,mayores,,efectos,,secundarios.,,cada,,,2,,,o,,,6,,,horas,,,ajustando,,,las,,,dosis,,,segn,,,el,,,dolor.,,,Porter,,,J,,,,Jick,,,H.,,,

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